Low values of gamma-glutamyltransferase are seen in conditions such as severe hepatitis and severely impaired liver function.
γ-Glutamyltransferase is an enzyme that catalyzes the transfer of γ-glutamyl group from glutathione to another peptide or another amino acid. It is found mainly on cell membranes and microsomes, and γ-glutamyltransferase in serum is mainly derived from the hepatobiliary system.
When severe hepatitis or liver function is severely impaired, it damages the cell membranes and microsomes of the hepatocytes, which causes a decrease in the source of γ-glutamyltransferase, leading to a decrease in its value.
When abnormal values of γ-glutamyltransferase in serum are found, attention should be paid to timely consultation, identification of the cause of the disease, and further treatment or therapy as prescribed by the doctor.