There is a piece of hard skin in the nose that hurts when pressed may be due to nasal vestibulitis, nasal vestibular cyst infection, chronic eczema, soft tissue malignant tumors and other factors. 1. Nasal vestibulitis: it is a diffuse inflammation of the nasal vestibular skin, related to the increase of nasal secretion, nose picking, plucking nasal hair and other factors, which can be manifested as redness and swelling of the skin of the nasal vestibule, pain, local skin thickening, erosion, cracks and other symptoms, and it may be complicated with boils in the nasal vestibule, cellulitis of the nose, and so on. 2. Nasal vestibule cyst infection: If there is a cyst in the nasal vestibule area, it may lead to the appearance of different sizes of bulges near the outer nose, and there is obvious pressure and pain when secondary infection occurs. 3. Chronic eczema: it is an inflammation of the superficial dermis and epidermis caused by a variety of internal and external factors. Chronic eczema can manifest local skin infiltration with dark red spots with papules, local skin hypertrophy, surface roughness, mossy changes, mostly accompanied by obvious itching, and secondary infection may lead to pain. 4. Soft tissue malignant tumor: when there is a soft tissue malignant tumor at the nose, it will also lead to the appearance of local lumps, accompanied by symptoms of pressure and pain. A piece of skin on the nose is hard and painful when pressed may also be caused by other factors, it is recommended that the patient consult a doctor in a timely manner, and actively cooperate with the relevant examination, in order to clarify the diagnosis and symptomatic treatment.