Patients with syphilis have different courses of penicillin application depending on the course of the disease. For stage I, stage II or early latent syphilis, when applying benzathine penicillin, once a week for a total of two times. In case of late syphilis and second stage recurrent syphilis, benzathine penicillin is applied once a week for a total of three times. Application of penicillin are one injection on each side of the buttocks, due to the large individual differences, medication does not exist the best, fastest, most effective, in addition to the commonly used over-the-counter drugs, should be under the guidance of a doctor, fully combined with personal circumstances, choose the most appropriate drug treatment, the choice of treatment plan must be accurate staging of syphilis before. Penicillin is the drug of choice for the treatment of all stages of syphilis, generally commonly used is benzathine penicillin, early detection of syphilis, timely and regular treatment, has a great impact on the prognosis.