Sacubitril valsartan including and timosartan composition, therapeutic effects, adverse reactions and contraindications are different. 1. Different composition: the composition of sakubatriz valsartan is sakubatriz and valsartan, and the composition of timosartan is timosartan, and the former belongs to the compound preparation. 2. Therapeutic effects are different: the main effect of sacubitril valsartan is anti-heart failure, and at the same time, it has the effect of lowering blood pressure, and the main indication of timosartan is hypertension. 3. Adverse reactions: the adverse reactions of sacubitril valsartan include edema, fall, abnormal red blood cell pressure accumulation, elevated blood potassium, elevated creatinine, etc., and the adverse reactions of timosartan include headache, dizziness, nausea, vomiting, influenza-like symptoms, gastroenteritis and so on. 4. Contraindications are different: patients with angioedema, cholestatic cirrhosis, severe hepatic damage are forbidden to use Sacubitril valsartan, patients with biliary tract obstruction, patients with severe renal insufficiency are forbidden to use timosartan. When using the two drugs, patients need to consult a professional physician’s opinion, and should not use the drug without authorization.