Denide cream is a hormonal cream which is a weak hormone that can be used to treat eczema, psoriasis, contact dermatitis, itchy nodular rash, lichen planus and other diseases. However, long-term application of hormones can produce some side effects, such as darkening of the skin, i.e. pigmentation, capillary dilation or skin folliculitis. Therefore, topical hormones are generally used sparingly on thin and tender skin areas such as the face, chest, and vulva, and are used under the guidance of a doctor as much as possible to avoid side effects.