Jaundice refers to the phenomenon of yellowing of the sclera, skin, mucous membranes and other tissues and fluids due to the elevated concentration of bilirubin in the blood. Common diseases that cause jaundice include cirrhosis, bile duct stones, hemolytic anemia, etc. Different causes lead to different medications, and there is no such thing as “the most effective medicine”, so it is important to consult a doctor in time and treat the cause. For jaundice caused by cirrhosis, common medications include antiviral drugs such as entecavir, interferon, liver-protecting drugs such as glycyrrhizic acid, bicyclic alcohol, etc. Glucocorticosteroids such as prednisone should be used as appropriate to reduce the damage of liver tissues and thus alleviate the jaundice symptoms. For jaundice caused by bile duct stones, appropriate antibiotics such as ceftazidime and clindamycin should be selected according to the results of blood culture and drug sensitivity test for anti-infective treatment, and at the same time, the obstruction should be actively contacted, such as percutaneous puncture for drainage of bile ducts, etc. Oral stone-dissolving drugs such as arbutinic acid can also be taken to remove jaundice according to the prescription of the doctor. For jaundice caused by hemolytic anemia, oral glucocorticoids such as dexamethasone and immunosuppressants such as cyclophosphamide can be given under doctor’s supervision, and blood transfusion therapy and folic acid supplementation can be given if necessary. Patients with jaundice should consult a doctor in a timely manner to clarify the cause of the disease, and then carry out targeted treatment, patients should not blindly self-medication, so as not to delay the condition.