Manidipine hydrochloride can be gradually discontinued when the blood pressure is under stable control, but not abruptly. Manidipine hydrochloride belongs to dihydropyridine calcium antagonist, has the effect of dilating peripheral blood vessels, clinically can be used in the treatment of patients with hypertension. Patients with primary hypertension usually need long-term oral drug treatment, if the patient’s blood pressure is well controlled, the drug can be gradually discontinued, but not suddenly. Secondary hypertension patients in the removal of triggering factors, blood pressure can return to normal, this time the drug can be discontinued, but under the guidance of the physician to adjust the discontinuation of the program. Adverse reactions to Manidipine hydrochloride include facial flushing, palpitations, sinus tachycardia, numbness of the tongue, dry mouth, sweating, headache, nausea, and loss of appetite. The drug is contraindicated in women who are allergic to the components of the drug and during pregnancy. Manidipine hydrochloride to lower blood pressure in the process, to follow the doctor’s instructions to use the drug, if the drug is discontinued to follow the doctor’s instructions, choose the appropriate stopping program.