Most of the pain in the late stage of lung cancer is persistent pain. The following reasons should be considered for the pain in the late stage of lung cancer: 1. Invasion of the pleura by lung cancer, which causes pulling of the pleura or invasion of the chest wall leading to pain, which is often persistent hidden pain, and in severe cases, respiratory difficulty and pleural effusion can also occur. 2. The pain in the late stage of lung cancer is also related to multiple bone metastases in the whole body, and multiple bone metastases lead to Pain is also often persistent and worsens at night. Systemic treatment mainly includes radiotherapy and chemotherapy for lung cancer, and radiotherapy and particle implantation for local metastasis pain to reduce pain. In short, advanced lung cancer pain is persistent pain.