Prostatic pain and perineal distension may be due to some urinary system inflammation, local tissue abscess, rectal cancer invasion and dissemination, etc. Symptomatic surgery such as abscess incision and drainage, etc., and medication such as norfloxacin, etc. are needed. 1. Inflammation of urinary system: when cystitis, urethritis and other diseases occur, bladder and perineum pain may occur. Drugs can be used for anti-infective treatment, and the commonly used clinical anti-infective drugs are quinolone antibacterial drugs such as ofloxacin and norfloxacin. However, the drug is prohibited for use under the age of 18, and can be replaced with penicillin and other drugs. 2. Local tissue abscess: when subcutaneous abscess, perianal abscess and other local tissue abscess occur, it may lead to perineal distension and prostate radiating pain, which can be treated with penicillin, cefuroxime and other anti-infective treatment, and ibuprofen and other antipyretic and analgesic medicines can be used for severe pain, if the abscess is serious, it is necessary to carry out incision and drainage of pus or drainage and other surgical treatments. 3. Invasion and spread of rectal cancer: when rectal cancer spreads to pelvic organs such as prostate, prostate pain and perineal distension may occur. Surgery is needed to remove the prostate gland, and bevacizumab, capecitabine and other medicines are needed to treat the prostate gland pain and perineum distension. There may be other causes of prostate pain and perineal distension, so patients should consult a doctor for timely examination and early treatment. All of the above drugs should be used under the guidance of a doctor.