The appearance of milia on the edge of the glans varies in medication depending on the cause. Pearly papules are the most common and can be treated with erythromycin ointment and Bactrim ointment. It may also be condyloma acuminatum, sebaceous gland ectasia, using phthalidin cream, tincture of pedicel fat or 90sr isotope dressing treatment. 1. pearly papules: if appear similar to small granulomatous protuberances, this disease should be considered. Most of them are caused by circumcision, and erythromycin ointment or mupirocin ointment can be applied. 2. Acromegaly: If there is a cauliflower-like protuberance, this disease should be considered. The drug treatment of this disease generally uses antiviral drugs such as phthalidomide cream or tincture of foot leaf grass fat. 3. Sebaceous gland ectasia: usually due to the abnormal accumulation of sebaceous glands leading to the appearance of flat papules on the affected area, may be related to the patient’s endocrine abnormality, at this time there are no obvious symptoms, the serious cases can be used 90sr isotope dressing. The above drugs should be used under the guidance of a doctor. This symptom may also be caused by other factors, requiring different treatment methods, patients should go to the regular hospital in a timely manner after the emergence of symptoms after a clear diagnosis, to carry out regular treatment, in order to avoid aggravation of the condition.