The treatment of high creatinine is divided into the following aspects: 1. active search for the cause; 2. oral medication; 3. renal replacement therapy; 4. strict dietary management. If it is caused by chronic renal failure, such as chronic glomerulonephritis, hypertensive kidney damage, diabetic nephropathy, etc., actively treat the original disease. If it is acute renal failure, prerenal factors can be appropriately supplemented with blood volume according to the cause. In case of nephrotoxic drugs, nephrotoxic drugs need to be discontinued, and hormone therapy for 3-5 days if necessary. If there are obstructive factors to lift the obstruction. If you reach the uremic stage, you need to perform renal replacement therapy, such as hemodialysis, peritoneal dialysis or kidney transplantation treatment. At the same time, both acute and chronic diseases require a strict low-salt, high-quality, low-protein diet, which can be combined with drug therapy to improve the patient’s prognosis.