Blood creatinine represents the glomerular filtration rate and kidney detoxification ability, and the increase of blood creatinine indicates the decrease of kidney detoxification ability. The treatment of high blood creatinine includes: 1, 3, with the use of kidney detoxification drugs to improve kidney function or delay the deterioration of kidney function; 4, when creatinine continues to rise and reaches the uremic phase, the kidneys have basically lost the ability to excrete toxins, this time should be timely renal replacement therapy to remove excess water toxins in the body, otherwise there will be pleural effusion, heart failure, hyperkalemia, coma, etc, Otherwise, pleural effusion, heart failure, hyperkalemia, coma and other manifestations will occur, and even life-threatening and irreversible damage will be caused. At present, the main ways of renal replacement therapy are hemodialysis, peritoneal dialysis and kidney transplantation, and different blood purification methods should be chosen according to different family situations and convenience.