The causes caused by high creatinine are the following: 1. Acute renal failure. Significant progressive elevation of blood creatinine, as an indicator of organic damage, may be accompanied by oliguria or non-oliguria. 2, chronic renal failure. The degree of elevated blood creatinine is consistent with the severity of the lesion. blood creatinine is less than 178umol/L in compensated renal failure, greater than 178umol/L in decompensated renal failure, and significantly elevated in renal failure, which can be greater than 445umol/L. High creatinine often indicates organic renal failure, prerenal oliguria, such as heart failure, dehydration, hepatorenal syndrome, nephrotic syndrome, etc. If the blood volume decreases and the renal blood flow decreases, the increase in creatinine concentration can occur, but usually does not exceed 200umol/L. The increase in creatinine caused by organic renal failure usually exceeds 200umol/L. Of course, we cannot exclude that some people who are well muscled or who work out and take a lot of protein may have a mild increase in creatinine, which may be relieved after controlling their diet. This may ease after diet control.