Tilmicosin is a macrolide antibiotic and oxytetracycline is a tetracycline antibiotic. 1. Tilmicosin: It is mainly used for the treatment of pneumonia caused by Mycoplasma, Actinobacillus, Bartonella and so on in domestic animals, and it can inhibit Gram-positive bacteria, some Gram-negative bacteria, spirochetes and mycobacteria, and so on. 2. Euthromycin: It mainly has antibacterial activity against canine rickettsiae, chlamydia, Borrelia burgdorferi, and also has antibacterial activity against canine and feline E. coli, and also has antibacterial activity against feline rickettsiae, and can be used for preventing canine leptospirosis, etc. It can also be used for preventing human rickettsiae, chlamydia, and leptospira. Tilmicosin can also be used for rickettsial disease, brucellosis, Mycoplasma pneumoniae infection, chlamydial infection, cholera, etc. in humans, as well as tetanus, syphilis, gonorrhea, leptospirosis, etc. in people allergic to penicillin antibiotics, and can also be used to treat acne. Tilmicosin is prohibited for sedation and may be fatal, the drug is toxic to the heart and may cause negative cardiac effects. Adverse effects of oxytetracycline are mainly affecting the development of bones and teeth, gastrointestinal reactions, and liver damage. Doxycycline hyclate should be used as prescribed by a physician.