Waking up in the middle of the night with a fast heartbeat may be due to autonomic dysfunction, cardiac neurosis, depression and other factors, which can be relieved by improving living habits and medication. 1. Autonomic dysfunction: Emotions and external environment may affect some organs of the body, causing temporary autonomic dysfunction disease, which may lead to the symptom of waking up in the middle of the night with a fast heartbeat. In daily life, it is recommended to participate in more outdoor activities, talk to people for psychological catharsis, and develop regular living habits. 2. Cardiac neurosis: Cardiac neurosis is a clinical syndrome mainly manifested by cardiovascular disease symptoms, which may lead to the symptom of waking up in the middle of the night with a fast heartbeat. It can be treated with oral medication such as metoprolol and propranolol under the guidance of a doctor. 3. Depression: Depression is a typical condition of depressive disorders, which can lead to the symptom of waking up in the middle of the night with a fast heartbeat. It is recommended that patients use fluoxetine, sertraline, bupropion and other drugs under the guidance of the doctor. Therefore, patients waking up in the middle of the night with a fast heartbeat are recommended to seek timely medical attention to clarify the cause of the disease and timely treatment. At the same time in the use of drugs during the treatment, be sure to quit smoking and alcohol, drugs need to consult a doctor before use, according to the doctor’s advice and guidance to use drugs for treatment.