Stubborn eczema is difficult to cure under normal circumstances, patients can improve the symptoms and relieve discomfort through lifestyle modification and medication. 1. Lifestyle regulation: patients are advised to have a light diet, avoid spicy and stimulating food, quit smoking and drinking, have a regular work schedule, avoid staying up late, keep a happy mood, take reasonable exercise, and keep clean and hygienic. 2. Drug therapy: local application of drugs such as mometasone furoate ointment, glycerite lotion, oral medication, including cetirizine, olopatadine and other drugs, if necessary, combined with Dupliyuzumab and other biologics treatment. Due to individual differences, drugs do not exist absolute effective and safe, should be used in accordance with medical advice to reduce or avoid adverse reactions, drug allergy is prohibited. After standardized treatment, stubborn eczema may be relieved or improved, because the disease is a chronic disease, it is difficult to be completely cured, so the patient should maintain a good attitude and actively accept treatment.