Small blisters on the soles of the feet are considered to be related to tinea pedis, palmoplantar pustulosis, eczema and so on. 1. Tinea pedis: If there is fungal infection in the local skin, the patient will have skin lesions such as skin flaking, blisters or localized skin impregnation and whitening, accompanied by obvious itching of the skin. 2. Palmoplantar pustulosis: the cause of this disease is not clear, mostly seen in middle-aged and elderly women, the patient is mostly manifested in the palms of the hands or soles of the feet recurring aseptic pustules, accompanied by itchy skin, pain and other discomforts. 3. Eczema: this disease occurs in genetic, environmental, mental, endocrine and other factors related to the patient mostly manifested as a symmetrical distribution of pimples, blisters, vesicles and other polymorphic lesions, accompanied by obvious itching of the skin. For patients with blisters on the soles of their feet, it is recommended that they go to the dermatology department of a regular hospital to clarify the cause of the disease and then actively treat it under the guidance of the doctor.