There is no such thing as 5 early symptoms of scleroderma, but early on there is damage to the skin, erythema, itching, and swelling. Scleroderma is a connective tissue lesion with an unknown etiology that may be influenced by genetic factors, and may also increase the chances of developing scleroderma in the presence of immunovascular damage or abnormal collagen synthesis. Symptoms of the disease generally vary from person to person. Some patients may experience limited skin lesions in the early stages, such as Raynaud’s phenomenon, edematous erythema, itchy skin, inflexibility, and swelling on the backs of the hands. In the later stages, the edema subsides and skin hardening, atrophy, and ulceration gradually appear. Scleroderma in the early stage can generally be treated with medication, you can use topical glucocorticoid ointment or anti-fibrotic drugs, such as cumenexin, penicillamine, vinpocetine. If the site of skin damage is relatively large, and drugs are difficult to control the condition generally need to choose surgical excision. Scleroderma patients are advised to go to the hospital in time to avoid delay.