Rheumatic immune diseases include rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, primary dry syndrome, osteoarthritis, and gout. They often involve multiple organs and systems. Ultraviolet light (especially B-spectrum) exposure from sunbathing can aggravate the condition of SLE patients. Approximately 70% of patients have disease activity due to UV exposure. Patients with lupus should not be exposed to direct sunlight for more than 15 minutes in high summer, with or without a rash. Exposure of DNA to UV increases thymine dimer, which is more immunogenic. Exposure of keratinized cells to UV light can induce apoptosis. During apoptosis, it can cause its own molecules to be exposed to the immune system and become immunogenic. UV damage to cells can produce heat shock proteins, which can be involved in the activation of autoreactive T cells. Other epidemiological studies have found a possible protective effect of UV exposure in multiple sclerosis and rheumatoid arthritis, but UV exposure has been found to increase the risk of autoimmune disease in genetically susceptible animal studies. Some studies have suggested that hair dyes and perms may increase the risk of SLE in women, but this is not recognized. Although it cannot be said with certainty that hair dye or eyebrow tattooing can induce lupus with certainty, at least a significant proportion of patients have had hair dye, eyebrow tattooing or breast augmentation for a short period of time prior to developing the disease.