Scleroderma is a disease characterized by limited or diffuse fibrosis or sclerosis of the connective tissue of the skin and internal organs. Scleroderma is a disease characterized by fibrosis or sclerosis of the skin and connective tissues of internal organs. Scleroderma can be divided into limited scleroderma and systemic scleroderma according to the clinical manifestations Limited scleroderma or scleroderma. The lesions are mainly confined to the skin, and the early damage is often limited to the distal extremities. The early damage is often limited to the distal extremities of the limbs or fingers and to the skin of the fingers. The internal organs are generally not involved and often resolve on their own with a good prognosis. According to the morphology of the lesions, the lesions are divided into: ①dotted scleroderma. (2) linear scleroderma. ③Frontal cutaneous scleroderma. ④Subcutaneous scleroderma. (5) Generalized scleroderma. (6) Disabling total scleroderma in children. Systemic scleroderma, also known as progressive systemic sclerosis, is characterized by diffuse fibrosis of the skin and internal organs, often involving the esophagus, lungs, heart and other internal organs, with a variable prognosis, mostly good, and a poor prognosis in diffuse cases. Depending on the clinical manifestations, the disease is classified into limbic, diffuse and CREST syndromes. The pathogenesis is complex, and the clinical manifestations include skin thickening and hardening to atrophy, Raynaud’s phenomenon, pulmonary hypertension and pulmonary fibrosis, kidney disease and damage to other internal organs. The skin manifestations are mainly skin symptoms The onset of the disease often starts from the hands, feet and face. It gradually spreads to the forearms and upper trunk, and is symmetrical. Localized erythema swelling occurs first, no depression when pressed, followed by firm and shiny skin, gray-yellow like wax, may have pigment abnormalities and capillary dilation. The skin cannot be lifted by fingers due to adhesion with subcutaneous tissue. The facial expression is lost in the form of a false mask, the tip of the nose resembles a hawk’s beak, and the lips are thinned and contracted into radial grooves. The mouth fissure is narrow. The finger joints are restricted in movement and may appear as claw-like hands. Elbow and knee joints may be flexed and contracted, and the skin of the chest may be involved and affect the whistling motion. The skin, subcutaneous tissue and muscles may be atrophied and the skin may be directly attached to the bone surface. The hair may be shed at the site of damage. Sweating is reduced and sebum is lacking. The nail may be widened, with a striated surface, fragile or thinning, and peeling off.