Limited scleroderma in children belongs to a kind of rheumatic immune disease, is a kind of localized chronic connective tissue disease in children, which is mainly manifested by localized skin thickening and fibrosis, and is usually mainly a characteristic change of the skin, and does not show the damage of internal organs. In children, limited scleroderma is mainly a hardening of the skin, and the lesions are often one or more purplish-red patches, which gradually thicken and harden from edema, and become yellowish or whitish in color. The majority of cases start on the hands, plaque scleroderma is more frequent on the trunk, and linear scleroderma is common in children, with lesions in the form of strips that are distributed along the unilateral limbs or intercostal nerves. These diseases are often associated with immunologic and genetic factors. Treatment can be improved through the early use of glucocorticoids such as prednisone, etc., the use of drugs need to be used under the guidance of a pharmacist.