Atopic dermatitis, also known as atopic eczema, is a clinically common chronic inflammatory disease of the skin,. Patients often have intense pruritus, which severely affects the quality of life. The disease usually begins in infancy and accounts for about 50% of all patients before the age of 1. The disease has a chronic course and can extend into adulthood in some patients, but there are also adult-onset patients. The symptoms of atopic dermatitis are varied, but the most basic features are dry skin, chronic eczema-like dermatitis, and severe itching. The majority of cases begin in infancy and early childhood, and some can occur in childhood and adulthood. Depending on the age of presentation, the disease is divided into three stages: infancy, childhood, and youth and adulthood. Infancy (from birth to 2 years) is characterized by infantile eczema, mostly on the cheeks, forehead and scalp, and the rash may be dry or oozing. Childhood ((2-12 years old) Mostly evolved from infancy, but also may not occur through infancy. The rash tends to be dry and hypertrophic, with obvious mossy changes. The lesions are similar to those of childhood, with subacute and chronic dermatitis mainly occurring in the elbow fossa, rouge fossa, and anterior neck, but also on the trunk, extremities, face, and dorsum of the hands, mostly with dry, hypertrophic dermatitis. The most common manifestations of atopic dermatitis are dry skin, ichthyosis, periorbital keratosis, palpebral striae, eyelid eczema, hand eczema, nipple eczema, discoid eczema, sweat scar rash, labyrinthitis, recurrent conjunctivitis, infraorbital folds, periorbital dark halo, pale face, anterior cervical folds, eczema in the subnasal and ear folds, white cutaneous scratchiness, painful itching during sweating, and sensitivity to wool.