Sebaceous ectasia is a disease of the sebaceous glands, first described by Fordyce in 1896 and therefore also known as Fordyee’s disease. The disease is due to a physiological variant of sebaceous gland development and sebaceous gland hyperplasia. It has been clinically observed that the disease does not only occur in the oral mucosa, but also in the foreskin and glans of men and the labia majora and minora of women. Ye Zhaolong et al. found 43 cases among the 772 women investigated, with a prevalence rate of 5.57%. The authors found 49 cases among 184 women in the STD clinic, with a prevalence rate of 26.63%; 76 cases among 209 men, with a prevalence rate of 36.36%. I. Etiology: The etiology of sebaceous gland ectopia is unknown. It is thought to be related to endocrine factors, local irritation or trauma. Clinical manifestations: Sebaceous gland ectopia occurs mostly after puberty, is more common in middle-aged people, and is more common in men than women. The disease occurs in the external genital area of the male mainly in the penile shaft, foreskin, tether, and rarely in the glans, and in women mainly in the labia majora and minora and perineum. The lesions are characterized by corn-sized flat papular lesions without obvious elevation of the skin, clustered, mostly pale yellow or a few pale white, some of which can fuse into dense irregular-shaped patches with a smooth surface, which can be seen more clearly when the skin is tensed and have a fine mud-like sensation when touched. The damage is mostly without conscious symptoms. Histopathological examination: In histopathology, small and mature sebaceous gland lobules are mainly seen around the sebaceous ducts. The reason is that any treatment is injurious and may cause secondary bacterial infections or scarring, etc. If the patient insists on removing the lesion, C02 laser treatment is feasible.