Back pain in patients with pancreatic cancer may be caused by spinal metastasis of the tumor, or caused by tumor invasion of the retroperitoneal nerve, or other diseases. Pancreatic cancer is a kind of malignant tumor of digestive tract with insidious onset, rapid progression, poor treatment effect and prognosis. Pancreatic cancer has insidious onset, early diagnosis is difficult, and most of the patients are already in the middle or late stage when they are diagnosed. Depending on the location and size of the tumor, the affected organs and its severity, pancreatic cancer patients may show epigastric or back pain, nausea, abdominal distension, jaundice, new-onset diabetes mellitus, weight loss and change of stool properties, etc. Occasionally, patients with acute pancreatitis as the main manifestation are seen. For patients with early pancreatic cancer, they may present with no specific symptoms or only intermittent/persistent epigastric pain, back pain, and gastrointestinal symptoms (loss of appetite, etc.), which may manifest as vague pain, distension, or dull pain. In addition, the pain may also be associated with a change in body position. In moderately advanced pancreatic cancer, persistent, severe abdominal pain can occur when the tumor invades the nerves from the abdominal cavity. Other diseases can also cause back pain, such as pancreatitis, pancreatic cysts, back cold or back fasciitis, etc., as well as trauma to the back can also have symptoms of pain. In addition, if you suffer from low back muscle, spine, liver and gallbladder system and kidney diseases, you will also have back pain. In conclusion, pancreatic cancer cannot be diagnosed by relying on a single back pain symptom. If you feel uncomfortable or suspect pancreatic cancer, it is recommended to go to a regular hospital for a comprehensive assessment of your condition and follow the doctor’s instructions for treatment to avoid delays.