The third booster shot generally refers to the third booster shot of the new coronavirus vaccine, which is usually available for thyroid nodules. The new coronavirus vaccine is an inactivated vaccine, and the booster shot can prevent the new coronavirus and reduce the possibility of infection with the new coronavirus. No significant adverse effects of the new coronavirus vaccine on the human endocrine system have been detected, and a third booster injection can be given for thyroid nodules. However, if the patient has obvious symptoms of hyperthyroidism or hypothyroidism, vaccination is not recommended and can be considered after the condition is stabilized. Allergies, acute illnesses, chronic disease exacerbations, patients with fever, and women during pregnancy are also not allowed to take the shot. After the third booster shot of the new coronary vaccine, attention should be paid to stay for 30 minutes and keep the wound dry for 24 hours to prevent infection. Patients are advised to inform their doctors in advance of their condition when receiving the third booster shot of the new coronavirus vaccine, so that the doctors can judge whether they can receive the vaccination.