Jin Gui Ren Qi Pill and Si Yi San can be used to treat cold hands and feet, but whether they can be used at the same time requires a doctor’s diagnosis and guidance. Jin Gui Kidney Qi Pill is composed of Di Huang, Poria, Chinese yam, etc. It has the effects of warming and tonifying kidney yang (warming and replenishing kidney yang), transforming qi to move water (promoting the movement of gases, thus promoting the movement of water and liquids), and can be used to treat coldness, limb coldness, edema, lumbar soreness and knee weakness, and cold hands and feet caused by kidney yang deficiency. It is contraindicated in pregnant women and used with caution in cases of Yin deficiency and internal heat. Sihui San is composed of Radix Bupleurum Chinense, Radix Paeoniae Alba, Radix et Rhizoma Glycyrrhizae Praeparatae and Citrus Aurantium Citri Reticulatae, it has the efficacy of dispersing the liver, regulating the spleen, and dispersing the heat by penetrating and resolving, it is mainly used for the symptoms caused by febrile convulsions such as warmth of the hands and feet and abdominal pain. The adverse reactions and contraindications of this product are not clear. In summary, the above two drugs have a certain therapeutic effect on cold hands and feet, but whether it can be used at the same time can not be generalized, the need for doctors to identify the guidance, if the patient at the same time there is heat syncope as well as renal yang deficiency, you can follow the doctor’s instructions for the joint use of drugs. It is recommended that patients with cold hands and feet first consult a doctor for examination, to clarify the specific causes of the disease, after diagnosis under the guidance of the doctor to standardize the treatment, do not take the same drug without authorization.