The treatment of psoriasis on the back of the hand includes topical medication, systemic medication, biologics, physical therapy, etc. It is recommended to consult a specialist and follow the doctor’s instructions for medication. 1. Topical drug treatment: use moisturizers to strengthen the skin protection on the back of the hand, glucocorticoid cream or ointment can be used, long-term use of attention to the adverse effects, etc. Other topical drugs can also be used, such as retinoic acid drugs such as retinoic acid cream, Vitamin D ā analogues such as Calcitriol, etc., or antikeratolytic drugs, such as tar preparations. 2. Systemic drug therapy: commonly used immune agents include methotrexate, cyclosporine, etc. Vitamin Dā analogs such as retinoic acid can also be used. Antibiotics are needed for skin infections, and penicillin is the most commonly used drug. 3. Biological agents: mainly refers to targeted immunomodulators, commonly used in the conventional treatment is ineffective or poorly tolerated moderate and severe psoriasis on the back of the hand, including enalapril, adalimumab and so on. 4. Physical therapy: such as photochemotherapy, 308nm excimer laser, and bath therapy can treat psoriasis on hands. Psoriasis on the back of the hand needs timely diagnosis and treatment under the guidance of doctors.