Sore throat as soon as swallowing saliva, generally is the manifestation of acute inflammation, such as acute pharyngitis, acute epiglottitis, acute tonsillitis, etc., need to be under the guidance of the doctor to carry out targeted treatment, such as medication and so on. 1. Acute pharyngitis, acute epiglottitis, there will also be obvious sore throat, aggravated by swallowing saliva. Acute pharyngitis caused by bacterial infection is often treated with antibiotics, penicillin is generally preferred; viral infection can be used as appropriate antiviral drugs, such as acyclovir. Acute epiglottitis sometimes occurs epiglottis edema obvious situation, commonly used glucocorticoids to reduce inflammatory edema, such as dexamethasone. 2. Acute tonsillitis will have sore throat, aggravated when swallowing saliva, or have systemic symptoms, fever, fatigue, etc.. Antibiotics as the main treatment, preferred penicillin drugs, such as amoxicillin, etc.; when the sore throat is more intense or high fever, oral antipyretic and analgesic drugs (such as ibuprofen, acetaminophen, aspirin, etc.). However, other factors can not be ruled out, it is recommended that the patient consult a doctor in a timely manner, by the doctor to clarify the cause of the disease, to give targeted medication and treatment, the choice of specific drugs and dosage forms should be used under the guidance of a specialist after examination, do not blindly self-medication.