White spots, also known as vitiligo, have an unknown cause and may be due to a variety of factors and may be hereditary. Creams that specialize in treating white spots include: glucocorticoid creams, calcium-modulated phosphatase inhibitors, and vitamin D3 derivatives. White spots are usually common in vitiligo, and early treatment of white spots can be done with glucocorticoid creams such as halometasone cream, betamethasone cream, clobetasone propionate cream, and hydrocortisone butyrate cream. Calcium-modulated phosphatase inhibitors: such as 0.1% tacrolimus ointment, 2% pimecrolimus cream. When the white spots are stable, 8-methoxypsoralen tincture and compound kalizan tincture can be applied for treatment. Also vitamin D3 derivatives can be applied, such as topical tacalcitol ointment. Patients who find white spots are recommended to seek medical treatment in time, and after clear diagnosis, they need to use medication under the guidance of doctors, and do not use it blindly on their own.