A loose and painful large tooth can be identified and treated with root canal therapy, periodontal therapy or extraction for the disease causing the tooth to become loose. The specific treatment should depend on the condition of the affected tooth. 1. Root canal therapy: A painful loose tooth caused by apical periodontitis can be treated with root canal therapy to remove inflammation, relieve pain, and promote recovery of the periapical tissues in order to improve the looseness of the tooth. 2. Periodontal treatment or extraction: periodontitis caused by tooth loosening, pain, the teeth should be on the gingival cleaning and subgingival scraping, completely remove the calculus around the teeth, plaque, to reduce the periodontal stimulation, and in the periodontal pockets placed in the anti-inflammatory drugs such as. However, for the extremely loose periodontitis, or the teeth in the center of the split, need to be extracted under local anesthesia. Loose and painful large teeth require prompt medical attention, examination and treatment under the guidance of a doctor to avoid delays.