Different sulfonylureas have their own characteristics and it is impossible to say directly which one is the best. Sulfonylurea hypoglycemic drugs are mainly used for non-insulin-dependent diabetes mellitus with unsatisfactory efficacy of dietary control alone, in which the patient’s beta pancreatic islet cells have certain insulin secretion function. Different sulfonylureas have their own characteristics, such as gliquidone can be used in diabetic patients with mild-to-moderate renal insufficiency, gliclazide and glipizide are available in controlled-release formulations that can be taken once a day, and so on. The main adverse effect of sulfonylureas is hypoglycemia and another adverse effect is weight gain. Skin irritation, gastrointestinal upset, drowsiness, neuralgia, jaundice and liver damage can also occur. Sulfonylureas should be used under the supervision of a physician and should never be used without authorization.