The vaccines currently marketed in China have been clinically tested, and if there are no contraindications to vaccination in the vaccinated person, there are usually no serious adverse reactions. In addition, there are more types of vaccines that include the third shot, commonly including the new coronavirus vaccine, rabies vaccine, human papillomavirus vaccine (also known as HPV), DPT vaccine, polio vaccine, etc. Although there are many types of vaccines, the third shot of different vaccines may have local and systemic reactions, and most of these adverse reactions are temporary and can be relieved with rest. If the adverse reaction is serious during home observation after vaccination, it is recommended to consult a doctor in time. 1. Serious adverse reactions: most of them occur within 30 minutes after vaccination, such as sudden pallor, drop in blood pressure, respiratory difficulties, etc., and in serious cases, even suffocation due to laryngeal edema. 2. General adverse reactions: localized redness, pain, hardness, itching and swelling in the injected area. It is recommended to avoid touching water locally on the day after vaccination to avoid aggravation of adverse reactions. Systemic reactions include low fever, dizziness, headache, fatigue, limb pain, coughing, loss of appetite, vomiting, diarrhea and so on. Therefore, in order to avoid serious adverse reactions, after vaccination, you need to stay in the vaccination site for 30 minutes, no discomfort before leaving, such as the emergence of serious adverse reactions is also convenient for timely rescue.