Uneven black and white skin color on the face may be due to vitiligo, simple furfura, anemic nevus and other reasons 1. Vitiligo: Related to the destruction of melanocytes due to genetic and immune factors, vitiligo can occur on the face, showing single or multiple white spots. It can appear in a variety of shapes, with clearer borders, and can cause uneven skin color on the face. 2. Furfura simplex: is a skin inflammation that develops on the face, and its occurrence may be related to microorganisms such as Malassezia furfur. The lesions are round or oval hypopigmented patches of varying sizes with slightly clear borders, which can cause uneven skin color on the face. 3. Anemic nevus: It is a rare, congenital skin disease caused by abnormal vascular development. It can cause hypopigmentation of the skin, appearing single or multiple, border clear but irregular pale white spots, which can appear uneven skin color on the face. In addition, it is recommended that patients with uneven skin color go to the hospital in time to get a clear diagnosis.