Entecavir is an antiviral drug that does not usually cause liver discomfort. Entecavir is commonly used in the treatment of active chronic hepatitis with antiviral effects. Entecavir’s adverse effects are mild and usually do not cause liver damage. As entecavir needs to be metabolized by the kidneys, patients with renal insufficiency should be advised to use entecavir with caution. The use of entecavir is contraindicated in patients who are allergic to entecavir components. The use of Entecavir may cause the body to experience dizziness, nausea, headache, fatigue and other adverse reactions, attention should be paid to use under the guidance of a doctor. If liver discomfort occurs while taking entecavir, it is necessary to consult a doctor in time, conduct relevant examinations to clarify the causes of liver discomfort, and carry out targeted treatment and treatment according to the cause.