Pancreatic head occupation, but CA199 is normal, it may be pancreatic pseudocyst, pancreatic cancer, insulinoma and other diseases, which can be treated by surgery, radiotherapy and chemotherapy. 1. Pancreatic pseudocysts: Pancreatic pseudocysts can also be found in the pancreatic head area, causing pancreatic head occupancy, but they do not cause CA199 elevation. Small pancreatic pseudocysts do not need special treatment and may be self-absorbed; larger pancreatic pseudocysts can be treated by internal drainage and external drainage. 2. Pancreatic cancer: pancreatic head occupation may be pancreatic cancer, and some pancreatic cancer patients’ tumor marker will not be elevated, i.e. CA199 is normal. Pancreatic cancer is mainly treated by pancreatic head duodenectomy, and radiotherapy and other comprehensive treatments are taken after operation. 3. Insulinoma: insulinoma is a benign tumor of pancreas, which can be manifested as pancreatic head occupation, but CA199 is normal, often causing hypoglycemic episodes. Small insulinoma can be removed by ultrasound-guided insulinoma resection, but Whipple’s operation is often performed for larger insulinoma in the pancreatic head. Pancreatic head occupation, but CA199 normal should go to the hospital in time to improve the examination, clarify the cause of the disease and then give targeted treatment.