Whether the 1st and 5th positive items in hepatitis B five tests are serious or not is related to whether the liver function is abnormal or not, if the liver function is normal, the condition is generally not serious. 1. Not too serious: if the patient receives ultrasound examination of the liver, which shows that the liver function is normal and the morphology and structure of the liver are normal, the condition is not serious and does not need special treatment for the time being, and only needs to be rechecked on a regular basis. 2. More serious: if the patient receives liver ultrasound examination, showing abnormal liver function, need to receive antiviral treatment, the severity of the disease needs to receive quantitative testing of hepatitis B DNA. The more common first-line antiviral drugs for hepatitis B include entecavir and tenofovir. In addition, Hepatitis B is a relatively common disease with a certain degree of danger, and it is recommended that after diagnosis, patients need to actively receive treatment under the guidance of specialists.