Itching of the body while sleeping may be caused by hives, pruritus, or diseases such as chronic eczema. It can be treated by general treatment, oral medication, and topical medication. 1. Urticaria: If there are dust mites on the bed sheets, pillows and quilts, allergy to dust mites can induce urticaria, which leads to itching of the body while sleeping. To diligently change the bed sheets, bedding, more sunshine, can effectively kill the mites, and oral cetirizine, loratadine and other antihistamines treatment. 2. Pruritus: diabetes, cholestasis and other diseases can cause pruritus, can also lead to sleep body itching, need to actively treat the original disease. 3. Chronic eczema: can be used externally hormonal ointment, such as halometasone, mometasone furoate ointment and other medication, but also oral loratadine and other antihistamines. Sleeping body itching, may also be caused by other reasons, need to go to the regular hospital to improve the relevant examination, clear cause for targeted treatment.