Whether or not joint pain returns to normal after stopping hormone medication is usually related to the way it is stopped, and joint pain can usually return to normal after gradually stopping the medication for a period of time. Hormones in medicine generally refers to glucocorticoids, a hormone that mainly affects the function of glucose metabolism, due to its relatively strong anti-inflammatory effect, also known as anti-inflammatory corticosteroid. It has anti-inflammatory, antitoxic, antiallergic, antishock, nonspecific immunosuppressive and antipyretic effects. Most glucocorticoids are used in diseases such as acute gouty arthritis and rheumatoid arthritis. Due to the wide range of hormone effects, many diseases require long-term oral hormone drugs. Due to human intervention, the hormone level of the body can be changed, and the body achieves a new dynamic balance of hormone levels through self-regulation, so the patient will also have a certain degree of dependence on hormones. When patients suddenly stop taking hormone medication, it is easy to cause withdrawal reaction, resulting in the patient’s arthralgia continues to exist, if according to the condition of the disease gradually and slowly reduce the amount of drugs until stopping, in the body gradually adapted to the changes in hormone levels, then within a period of time to make the arthralgia return to normal. If patients need to stop taking hormones, it is recommended that they stop taking them under the guidance of a physician to avoid adverse effects.