Candesartan and valsartan are not recommended to be taken at the same time. Candesartan and valsartan are both angiotensin II receptor antagonists (ARB), the same type of hypertension drugs are not recommended to be taken at the same time, the effect is not significantly improved, but may also cause an increase in adverse reactions. According to China’s hypertension prevention and treatment guidelines, the combination of hypertension, the choice of antihypertensive drugs need to have a complementary mechanism of action, and at the same time have additive antihypertensive effect, it is best to offset each other or reduce the adverse effects. Combination of similar drugs is not recommended.ARB drugs are recommended to be combined with diuretics (hydrochlorothiazide, etc.), dihydropyridines (nifedipine, etc.) drugs, and are not recommended (or used with caution) to be combined with beta-blockers (metoprolol, etc.). ARBs such as candesartan and valsartan are contraindicated in people who are allergic to ARBs, people with more severe renal insufficiency, pregnant women, and diabetic patients not to be combined with aliskiren. Adverse reactions mainly include headache, dizziness, cough, diarrhea, abdominal pain, fatigue, etc., occasional neutropenia, occasional liver function abnormalities. Specific drug use or combination should follow the guidance of the clinician, do not choose on your own to avoid adverse effects.