Maintenance therapy for lung cancer is not recommended to be stopped. Maintenance therapy for lung cancer is a continuous treatment to avoid recurrence of lung cancer after first-line chemotherapy, the main purpose is to maintain the current state of patients so as to avoid continuous deterioration of the condition. Generally speaking, the maintenance therapy should be insisted on until there is a new progression of the condition or intolerance, and should not be stopped casually if there are no special circumstances. Maintenance treatment for lung cancer is mainly based on chemotherapy, and pemetrexed, bevacizumab and other chemotherapeutic drugs can be used for single treatment or combined treatment, and the specific time and treatment plan need to be combined with the patient’s physical condition and disease to determine; if there is any deterioration, then second-line treatment is needed.