Large weight knee pain requires weight reduction, application of medication, and physical therapy. Large weight knee pain consider the lower limb joints bear too much load caused by joint wear and tear, this situation should reduce walking, car instead of walking. Usually can swim, cycling, exercise to reduce weight, reduce joint pressure. If the pain is obvious, you can apply non-steroidal painkillers, such as oral celecoxib or etoricoxib, and topical flurbiprofen. You can also have a closed injection at the pain point. Physical therapy can take ultrasound physiotherapy, heat packs, waxing, ultrashort wave physiotherapy. If the rest does not alleviate the knee pain, go to the hospital and take an X-ray if necessary to determine whether there is any arthropathy and further treatment.