Generalized fever but feeling cold is a common clinical symptom after fever and during the period of rising body temperature. There are many causes of fever, if it is caused by bacterial infection, antibiotic treatment can be carried out, if it is caused by neurological disorders, B vitamins can be taken for treatment, if it is caused by oncological diseases, need to clarify the cause of the symptomatic standardization of treatment, the use of medication should be taken in accordance with the doctor’s instructions. 1. Bacterial infections: In the case of bacterial infections with clear causative factors, sensitive antibiotics are usually used for anti-infective treatment, such as penicillin or levofloxacin and other drugs, and Chinese medicines such as Xiao Chaihu Granules can also be taken as prescribed by the doctor to relieve the symptoms and reduce fever. 2. Neurological dysfunction: autonomic dysfunction mostly affects normal thermoregulation, which may lead to fever symptoms. While ensuring sufficient rest, B vitamins can be taken as prescribed by the doctor for nutritional nerve treatment, such as vitamin B12 or methylcobalamin. 3. Tumor disease: Infection in the body will basically appear fever symptoms, for tumor disease, usually appear “unexplained” fever, need to be clear through the cause of the disease, timely exclusion of possible tumor lesions, to the cause of the formal treatment. In daily life, if the fever is not high and there is a slight chill, it is usually recommended not to reduce the fever in a hurry, avoid taking antipyretic drugs to cover up the condition, and consult a doctor in time to clarify the cause of the disease. For recurring fever or high fever, first physical cooling and then timely medical examination to clarify the cause of the disease, follow the doctor’s instructions for standardized treatment.