Fluid with edema in the wrist should be medicated according to the cause of the disease, and the common causes are trauma, fracture, rheumatism or rheumatoid arthritis, gout, and infections of the peripheral tissues. Therapeutic drugs are anti-inflammatory and analgesic drugs, anti-infective drugs, uric acid-lowering drugs and so on. 1. Trauma: when hand trauma leads to hand infection, local abscesses will appear, at this time to actively use penicillin and other anti-infective treatment. 2. Fracture: hand fracture damage to the surrounding soft tissues and muscles resulting in local bleeding, but also the formation of abscess, this time to bed rest, elevate the patient, within 72 hours of the fracture site of the ice packs, 72 hours after the change to hot packs, but also with ibuprofen and other non-steroidal anti-inflammatory analgesic drugs in order to promote the subsidence of swelling. 3. Rheumatism, rheumatoid arthritis: generally use methotrexate, salazosulfapyridine and other treatments. 4. Gout: mostly caused by high uric acid, this kind of disease will also appear in the wrist of fluid and edema, this time to use the uric acid lowering drugs such as allopurinol, febuxostat and so on. 5. Infection of the surrounding tissues of the wrist: resulting in edema and effusion should be actively anti-infective treatment such as the use of penicillin, erythromycin and so on. There may be other reasons for fluid accumulation and edema in the wrist, such as acute lymphadenitis, heart failure, venous embolism in the hand, hypoproteinemia in renal disease, etc., and it is recommended to consult a doctor in time when the above situation occurs. The above drugs need to be standardized and rationally used under the guidance of professional physicians and pharmacists.