Hemoglobin a2 of 5.2% is common in thalassemia. Mild thalassemia can be treated without special treatment when there are no obvious symptoms, but if it is moderate or severe thalassemia, it needs to be treated. 1. If thalassemia is diagnosed, mild patients usually have no obvious symptoms and do not need special treatment. 2. For moderate to severe thalassemia patients, regular blood transfusion and other treatments are needed, and iron removal treatment can be combined with drugs such as Deferasirox. Hemoglobin a2 is a kind of hemoglobin, belongs to the hemoglobin electrophoresis in the more commonly used indicators, can reflect the body with or without thalassemia, the normal value of hemoglobin a2 is 2.5%~3.5%, more than the normal value is commonly found in thalassemia, but can’t be used as the basis for diagnosis, thalassemia line gene test can be a clear diagnosis. When hemoglobin a2 exceeds the normal value in clinic, we should improve the examination to clarify the cause of the disease, and then carry out the corresponding treatment under the guidance of physicians.