A transaminase of more than 1,000 and an alpha-fetoprotein of 300 indicate that there is serious liver damage, and the patient needs to go to the hospital in time for examination, identify the cause of the disease, and actively cooperate with the doctor for treatment, of which the common treatments are medication and surgical treatment. Transaminases and alpha-fetoprotein are both commonly used indicators for detecting liver diseases, of which transaminases can reflect the degree of damage to liver cells, with a normal range of about 120 U/L or less. If the transaminase level reaches over 1,000, it indicates that the liver cells may be suffering from acute inflammation and necrosis, and the liver cells are severely damaged. In addition, alpha-fetoprotein is an important glycoprotein indicator that reflects liver cancer and liver cell regeneration, and its normal value is about 25 μg/L. When the actual value of alpha-fetoprotein reaches 300, it indicates that there may be liver cancer. At this point, patients are advised to go to the hospital as soon as possible to receive further examination to clarify the specific cause of the disease, and under the guidance of the doctor to carry out antiviral treatment, which commonly used drugs include entecavir, tenofovir and so on. However, if the condition is more serious and drug treatment cannot achieve significant results, surgical treatment can be chosen. During the treatment, patients should strictly follow the doctor’s arrangement, do not self-medicate, and at the same time, strengthen the daily care, so as not to aggravate the condition.