The principles of treatment for acute mastoiditis are anti-infection, unobstructed drainage, and elimination of the cause of the disease. Systemic treatment: 1. Apply sufficient amount of antibacterial drugs to control the infection as early as possible to ensure complete cure to prevent complications or transformation into chronic. Generally, penicillin G can be combined with ampicillin, and the second generation cephalosporin cefuroxime can be applied among cephalosporins. After tympanic membrane perforation, pus should be taken for bacterial culture and drug sensitivity test, and appropriate antibacterial drugs should be selected with reference to the results.2. Nasal decongestants should be applied to the nasopharynx by nasal drops or spray.3. Pay attention to rest, regulate diet, and unblock bowel movements. Local treatment: 1. 2% glycerol drops of glycolic acid can be used before tympanic membrane perforation to relieve inflammation and pain. 2. Tympanotomy can be performed at the right time to facilitate drainage. After tympanic membrane perforation, ear drops of 3% ofloxacin can be applied. 3. Etiological treatment, active treatment of chronic diseases of the nose and pharynx. If the infection cannot be controlled by treatment or if there are suspected complications, mastoid opening should be performed immediately.