Severe protein loss and swelling of the body should be preceded by a search for the cause of the protein loss, which in clinical practice is most commonly due to liver disease and kidney disease. Patients with severe hypoproteinemia need to be supplemented with intravenous infusion of human albumin, while actively searching for the cause of the disease. Severe protein loss due to liver disease is mainly due to cirrhosis. Patients with cirrhotic ascites lose protein from their bodies along with the ascites. This leads to hypoproteinemia in the body appearing as peripheral swelling. This condition requires symptomatic treatment with liver preservation and protein infusion. If the body is swollen due to protein loss caused by kidney disease, the common kidney diseases are chronic glomerulonephritis and nephrotic syndrome. This situation needs to do renal puncture, clear pathology of sex medication, in the clinical commonly used drugs are hormones and immune agents treatment, such as prednisone, prednisone, cyclophosphamide, tacrolimus and so on. Protein loss severe body swelling, should promptly seek medical attention, clear diagnosis, standardized treatment.