Low globulin may be caused by malnutrition, immunocompromise, drug reaction, hepatitis and so on. 1. Malnutrition: Protein is the component of globulin, and long-term malnutrition will lead to the phenomenon of low globulin. We should ensure balanced nutrition and eat more protein-rich food. 2. Low immune function: If the patient has congenital or acquired immunodeficiency, resulting in low immune function, the globulin will also be low. 3. Drug reaction: the treatment of some diseases may require the use of immune agents, if the recent use of such drugs, the immune system will undergo some changes, the low globulin will occur. 4. Hepatitis: low globulin can also be caused by inflammation or lesions in the liver, such as hepatitis, bile buildup can also trigger hepatitis, when inflammatory lesions occur in the liver, low globulin can also occur. There are many reasons for low globulin, so it is recommended that patients go to a regular hospital for further examination to identify the cause of the disease and then carry out targeted treatment.