The particularly dark nipples of girls may be physiological phenomenon, or may be caused by endocrine reasons, breast diseases, etc. Different treatments need to be taken according to different reasons, including no special treatment, laser treatment, medication, surgical treatment and other ways. 1. Physiological phenomenon: such as pigmentation, hereditary reasons and other causes of nipple melanin increase, can be manifested as nipple especially black. Generally there is no need for special treatment. If the symptoms are more serious, laser treatment can be used to get rid of the black effect, and the normal color can be restored after the treatment of nipple, and good protection and maintenance should be done after the treatment. 2. Endocrine reasons: recent stress, mental tension and other conditions lead to endocrine disorders, may also appear nipple especially black, need to adjust lifestyle habits, consult a psychologist and other ways to regulate. 3. Breast diseases: Blood overflow caused by diseases such as breast cancer, causing the visual sensation of darkening. At this time, surgical excision, chemotherapy (e.g. applying drugs such as doxorubicin and paclitaxel), radiotherapy, endocrine therapy (e.g. applying drugs such as tamoxifen and toremifene), targeted therapy (e.g. applying drugs such as trastuzumab and lapatinib) and other treatments may be needed. The specific treatment should be chosen by the doctor according to the patient’s specific situation. In addition to the above reasons, there may be other reasons why girls’ nipples are particularly dark. It is recommended that girls with this condition should go to the hospital for a complete examination in a timely manner to clarify the specific causes and then follow the doctor’s instructions to choose the appropriate treatment, and the drugs should be applied under the guidance of the doctor.