How to treat psoriasis Adrenocorticotropic hormone was first successfully taken and clinically researched by Hench and others in the United States in 1948, and was officially used in the clinic in 1949, which was actually crude kojicones extracted from the adrenal cortex of animals, mainly for the treatment of rheumatic diseases. Hormones are considered to be a major breakthrough in clinical drug therapy after antibiotics, and one of the biggest discoveries in medicine in the 1940s. It is believed that the discovery of antibiotics in the 1930s opened up a new and broad path for the treatment of exogenous pathogenic factors such as bacteria, viruses, mycoplasma, rickettsia and parasitic diseases, while the discovery and clinical use of adrenocorticotropic hormones in the 1940s was a new breakthrough in terms of the body’s inherent ability to fight disease. Psoriasis is an inflammatory polygenic genetic disease associated with various factors such as immunity. Since glucocorticoids have anti-inflammatory, anti-allergic, immunosuppressive, anti-toxic and anti-nuclear division effects, the use of glucocorticoids has obvious efficacy in the treatment of psoriasis. The use of glucocorticosteroids includes oral and topical application. Although the systematic application of glucocorticoids for the treatment of psoriasis has remarkable efficacy, it can relapse rapidly after stopping the drug, and it is often more difficult to treat again. Suddenly stopping the drug or reducing the dosage too quickly can also induce pustular psoriasis, and long-term use can produce a series of side effects, such as hypertension, diabetes, ulcer disease and centripetal obesity, so it should be applied carefully. For certain erythrodermic, arthritic and generalized pustular psoriasis, glucocorticoids can be systematically applied in combination with other drugs when other measures are ineffective, while they should not be systematically applied for common psoriasis. Some “charlatan doctors” have the signboard of treating psoriasis with their ancestral recipes, promising “instant results”, “one shot”, “root cure “The actual fact is that you can find a lot of people who have been in the business for a long time, and they have been in the business for a long time. Topical glucocorticoid preparations have been routinely used in the treatment of psoriasis for decades, and they are very effective in controlling the symptoms of psoriasis, and the effect is relatively rapid, slowing down the overgrowth of psoriatic skin cells and reducing the inflammation of the lesions, but they do not guarantee long-term relief, and are prone to relapse after discontinuation, and can cause drug resistance and skin atrophy, thinning, capillary dilation, pigmentation However, they cannot guarantee long-term remission and are prone to relapse after discontinuation, and can cause drug resistance and adverse reactions such as skin atrophy, thinning, capillary dilation, hyperpigmentation, and local hirsutism. Many people know that hormones have side effects, and some psoriasis patients are psychologically more reluctant to use hormone creams to treat their diseases. In fact, this is not necessary. Although there are adverse reactions to hormones, the severity of the adverse reactions varies according to the application site, scope, course of treatment, method and strength of the drug. Patients should learn to use topical glucocorticoids correctly to avoid unwanted side effects. Generally, glucocorticosteroids that are more potent are more effective in treating psoriasis, but also have more side effects. The dosage form of the glucocorticosteroid also affects how much of the drug penetrates into the tissues. Glucocorticosteroid medications come in different dosage forms such as creams, ointments, emulsions, sprays, solutions, lotions, foams or tapes. Weak, less potent glucocorticoids are commonly used to treat thin, sensitive skin such as the face, groin and chest. These areas are most susceptible to glucocorticoid side effects, so even weak glucocorticosteroids should be used with caution. Treatment of lesions on the face, skin folds or genital areas must be done under medical supervision. Stronger glucocorticosteroids are more suitable for treating thicker skin such as the knees and elbows. In the vast majority of cases, topical use of weak to moderately potent topical glucocorticosteroids on the body of children is safe. Several uses of topical glucocorticosteroid preparations: 1. Sequential therapy: first apply super- or strong-acting corticosteroids topically to a small area of thicker lesions, and then use medium- or low-acting corticosteroid preparations after the lesions have thinned. There is also the problem of “rebound” of skin lesions when topical hormone drugs are suddenly stopped. Therefore, when the lesions subside or when you are ready to switch to other drugs, do not suddenly stop using hormone drugs, but gradually reduce the number of times you apply the drugs and then slowly stop using them. In this way, the sudden recurrence or aggravation of skin lesions can often be prevented. 2.Intermittent shock therapy: Use super-potent corticosteroid preparations for small area topical application for 2 to 3 weeks, twice a day, and when the lesions become thinner, the number of rashes is reduced or the lesion area fades by more than 80%, change to continuous medication 3 times a week, with an interval of 12 hours each time. Or use weekend therapy, that is, use non-hormone cream from Monday to Friday, and use hormone cream for 2 days in a row on the weekend. 3. Combination therapy: Corticosteroids and tar, salicylic acid, tazarotene, anthralin, vitamin D, etc. are made into compound preparations or alternatively used topically, which can not only enhance the therapeutic effect but also reduce the adverse drug reactions. 4.Encapsulation therapy: glucocorticoid drugs are used for psoriasis lesions and covered with impermeable plastic cloth, cling film, etc. to reduce the evaporation of local moisture from the skin and promote the softening of the skin surface, so that the drugs are more easily absorbed by the skin and achieve therapeutic effects. Generally for those lesions that are plaque type or too thickly keratinized. In addition to mastering the application method, area, dosage form and dosage, the correct application of corticosteroid topical preparations for the treatment of psoriasis should also strictly grasp the indications and cautiously apply strong corticosteroids, pay attention to the sequence of drug application, and avoid the combined use of different dosage forms or the same kind of corticosteroids, such as LeSkin Liquid and EnSkin Cream, LeSkin Liquid and Clofloxacin coating film, etc., in order to guarantee the maximum therapeutic effect and the minimum adverse reactions. Patients should use medication under the guidance of a specialist, avoid long-term large area use of corticosteroids, and the longest continuous use of hormone topicals should not exceed 3 months in general.